The effect of Renin Aldosterone Angiotensin II System on adrenal glands and glomerular filtration rate in renal failure patients

Abstract

Renin Aldosterone Angiotensin-2 Systems: Among the most important hormone structures, it controls blood sugar levels, potassium and salt equilibrium, the amount of fluid, and the activities of the urinary tract, the adrenals, and the heart and arteries. The purpose of this investigation is to look at how Renin Aldosterone Angiotensin II affects the glands that produce adrenaline and how it relates to the rate of glomerular filtration in people with persistent kidney disease. The Ibn Sina Centre at Baquba University Hospital is home to 100 Iraqi patients with chronic kidney failure, ranging in age from 35 to 67. The formula was used to get a glomerular filtration rate (GFR). All individuals' blood levels of the hormones renin, testosterone, and angiotensin-2 are measured using a readily accessible ELISA Micro water sources kit from LDN, Germany. The findings demonstrate the relationship among variations in GFR and activity a hormone called ; in the cautious category, the average GFR was substantially inversely correlated with the average activity a hormone called (r=-0.40, p<0.01). The findings demonstrated a relationship among ANGII, aldosterone, and cortisol variations in serum-activated renin, or The average blood activated a hormone called level and the average aldosterone level exhibited an important positive connection in the control group (r=0.33, p<0.05). In contrast, the hemodialysis group (r=-0.12, p>0.05) and the two categories (r=-0.02, p>0.05) showed insignificant negative correlations. In the more cautious group, there was a strong positive correlation (r=0.55, p<0.01) between the mean blood angiotensin level and mean cortisone. In individuals with chronic renal failure, glomerular filtration rate has a detrimental impact on active renin, which in turn has an impact on the adrenal cortex function