Biochemical changes in overweight and obese patients after taking 5 mg of Tadalafil for two weeks

Abstract

Background: obesity enhances a chronic inflammation and oxidative stress and damages the vascular endothelium. Tadalafil restores signaling of NO signaling and may decrease circulating oxidative stress and   markers of inflammation, and improves  parameters of  metabolism   through a number of mechanisms. The aim of this study to show what the effects of   the administration of tadalafil (TAD) on inflammation, and oxidative stress markers in obese male patients.

Methods: 32 male  subjects  with BMI more than 23 and age range 30-50 years old  underwent with TAD 5mg for 14 days .Plasma level of MDA , GsH ,IL-6 and Hs-CRP before the taking of drugs  and after 14 days of  treatment .

Results: Treatment with TAD caused a non-significant reduction in MDA group (0.093±0.027 versus 0.082± 0.032, P- value is 0.196), a non-significant increase in plasma GsH (0.1074±0.007 versus 0.109±0.009 ,  p-value is 0.538), a non-significant  of reduction in plasma level of plasma  Hs-CRP and IL-6  (4.377± 0.702 versus 4.272± 0.693, p-value is 0.599) and (24.668± 6.001 versus 23.56± 2.587 ,p-value is 0.401)respectively .

Conclusion: We have concluded that TAD therapy has non –significant effect on anti-inflammatory and anti-oxidant activity if used in short term but this effect may be significant if used for long term or use large dose